Beilstein J. Org. Chem.2017,13, 2819–2832, doi:10.3762/bjoc.13.274
-the art methods and give directions for choosing the appropriate approach. We also discuss the preparation and properties of mRNAs with non-natural caps providing novel features such as improved stability or enhanced translational efficiency.
Keywords: cap analogue; capsynthesis; click chemistry
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Graphical Abstract
Figure 1:
Schematic representation of enzymatic 5′-cap formation in eukaryotic mRNA. The 5′-triphosphate-end ...